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Q:What's protein methylation? A: Protein methylation is a kind of stable post-translational modification with important biological functions. Recent works show that protein methylation is implicated in several important biological processes including protein-protein interaction, cellular localization, and signal transduction. In particular, methylation is an important part of the histone code that regulates cell type¨Cspecific gene expression programs. What¡¯s more, bioinformatics analyses predict that there are numerous putative methyltransferases in yeast. Hence methylation may be a far more important and universal PTM than previously thought. Q:What's SVM? A:The support vector machine (SVM) is a new machine learning method, which has been used for many kinds of pattern recognition problems. The principle of the SVM method is to transform the samples into a high dimension Hilbert space and to seek a separating hyperplane in this space. The optimal separating hyperplane, is chosen in such a way as to maximize its distance from the closest training samples. As a supervised machine learning technology, SVM is well founded theoretically on Statistical Learning Theory. The SVM usually outperforms other traditional machine learning technologies, including neural networks and the k-nearest neighbor classifier. Q:How to use MEMO? A: It's simple! Click the "Input Form" button at the left,then input your protein name and its sequence. After clicking on "Submit" you can see your query's result. MAKE SURE that you HAVE read the INSTRUCTION under the input form. That's all, enjoy MEMO! Reference: in submit. |