Introduction

Knowledge of subcellular localization is crucial to understanding protein function and biological process. During translation or later, proteins will be transported into different compartments such as cytoplasm, membrane system, mitochondrion, etc., or may be secreted out of the cell. Locating to a specific subcellular compartment is essential for a protein to function efficiently.

Furthermore, a lot of proteins have more then one subcellular localization annotations. These proteins may simultaneously locate or move between different cellular compartments, for example, transcription factors and signaling pathway transduction factors. Proteins may play different roles in biological process when they are in different subcellular localizations. To these proteins, single subcellular localization annotation will lose some important information. Usually these proteins have more important biological function. Their localization annotations will provide more valuable clues to researchers. Here we have built the DBMLoc collect proteins with multiple subcellular localization annotations, which may provide useful information for protein functional research as well as computational prediction.