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 Research Interests
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My research interests focus on the modeling and dynamical analysis of cell signal transduction pathways by computational simulations. |
| Research Experiences |
 In Silico Identification of the Key Components and Steps in IFN-γ Induced JAK-STAT Signaling Pathway |
In this work, we developed a new way to globally identify the key components and steps in cellular signal transduction networks at a systems level. This is investigated upon a mathematical model of IFN-γ induced JAK-STAT signaling pathway by applying multi-parametric sensitivity analysis (MPSA) which is based on a Monte-Carlo method over a broad range of simultaneous variation in parameters. |
| Robustness Analysis on JAK-STAT Signaling Pathway |
We implement the robustness analysis on JAK-STAT signaling pathway by systematically varying the kinetic parameters values of this signaling pathway. This study demonstrates that the JAK-STAT signaling pathway is robust with respect to its 'signal time' and 'signal duration', but sensitive with respect to its 'signal amplitude'. |
Mathematical Modeling of TGF-β Signaling Pathway |
Now I am working on the mathematical modeling of another important signaling pathway, TGF-β signaling pathway. |
CopyRight Zhike Zi ©
Last Modified:October 15, 2004
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