Personal Information

First Name: Zhike

Last Name: Zi

Birth: 1979

Gender: Male

Citizenship: P.R. China

Education

09/2002 - 07/2005

M.S. in Bioinformatics at Department of Biological Sciences and Biotechnology,  Tsinghua University, Beijing, China .

Supervisor: Zhirong Sun

09/1998 - 06/2002

B.S. in Biotechnology at College of Chemistry and Life Science, South-central  University for Nationalities, Wuhan, China.

Skills

Language

Chinese: Native Language

English: Proficient in reading, listening, speaking and writing.

Computer

High Level Languages: Matlab, C

Operating Systems: LinuX, MS-Windows

Packages: MS-Office, Photoshop, Illustrator

Research Interests

Research Experiences

One of my previous works is "In Silico Identification of the Key Components and Steps in IFN-γ Induced JAK-STAT Signaling Pathway". In this work, we developed a new way to globally identify the key components and steps in cellular signal transduction networks at a systems level. This is investigated upon a mathematical model of IFN-γ induced JAK-STAT signaling pathway by applying multi-parametric sensitivity analysis (MPSA) which is based on a Monte-Carlo method over a broad range of simultaneous variation in parameters.

Another work is about robustness analysis on JAK-STAT signaling pathway by systematically varying the kinetic parameters values of this signaling pathway. This study demonstrates that the JAK-STAT signaling pathway is robust with respect to its 'signal time' and 'signal duration', but sensitive with respect to its 'signal amplitude'.

Now I am working on the mathematical modeling of another important signaling pathway,TGF-β signaling pathway.

Contact

Email:zzk02 at mails dot tsinghua dot edu dot cn or zizhike at tsinghua dot org dot cn

Homepage: www.bioinfo.tsinghua.edu.cn/~zzk